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Source: Reuters Health
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Abstract

Fresh remedies are essential for patients with severe bronchial asthma. We hypothesized that the scientifically relevant experimental imitation of house dust mite (HDM)-caused murine bronchial asthma could be employed to learn fresh paths that regulate disease severity. In HDM-challenged rodents, genome-wide expression profiling from the asthmatic lung transcriptome recognized apolipoprotein E (apoE) like a steroid-unresponsive gene with regularly upregulated expression despite dexamethasone treatment. ApoE and low-density lipoprotein receptor (LDLR) knockout rodents were utilised to show that apoE, that is created by lung macrophages, functions inside a paracrine fashion by binding …

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