Authors: Grayfer L, Hodgkinson JW, Belosevic M
The slow rate of growth of Mycobacterium spp. that infect humans combined with deficiencies in reliable in vitro infection imitation systems has impeded the progress of research in host cell-mycobacteria interactions. Recent reports have utilized the relatively quick growing Mycobacterium marinum to look at the host-virus interface in natural seafood hosts. Ideas describe the employ of primary fish monocyte and mature macrophage cultures to research the immune cell-M. marinum interactions. Live and warmth-wiped out M. marinum abrogated the recombinant fish (rg)TNFα2 and rgIFNγ-caused monocyte reactive oxygen production. Live however not warmth-wiped out M. marinum also ablated rgIFNγrel and rg-TNFα2 caused macrophage nitric oxide supplement producti...
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