Research into the antimicrobial reactions of primary phagocytes from the fish (Carassius auratus L.) against Mycobacterium marinum.

Authors: Grayfer L, Hodgkinson JW, Belosevic M

Abstract

The slow rate of growth of Mycobacterium spp. that infect humans combined with deficiencies in reliable in vitro infection imitation systems has impeded the progress of research in host cell-mycobacteria interactions. Recent reports have utilized the relatively quick growing Mycobacterium marinum to look at the host-virus interface in natural seafood hosts. Ideas describe the employ of primary fish monocyte and mature macrophage cultures to research the immune cell-M. marinum interactions. Live and warmth-wiped out M. marinum abrogated the recombinant fish (rg)TNFα2 and rgIFNγ-caused monocyte reactive oxygen production. Live however not warmth-wiped out M. marinum also ablated rgIFNγrel and rg-TNFα2 caused macrophage nitric oxide supplement producti...

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