Cerebrovascular Accidents Connected with Sorafenib in Hepatocellular Carcinoma

We report two cases of individuals with hepatocellular carcinoma who developed a cerebrovascular accident while on sorafenib. Neither patient had any danger elements for the cerebrovascular events apart from gender and age in the second patient. Laboratory data had been noncontributory. The head CT scan did not reveal acute abnormalities. No hemodynamically significant stenosis was visible in the carotid ultrasound, and the echocardiogram showed normal quantity of the heart chambers and normal systolic function of the left ventricle. Sorafenib was discontinued in each cases. Physicians should monitor individuals receiving sorafenib for neurologic symptoms, and in the absence of other etiology, prompt discontinuation of this drug should be considered. (Supply: Clinical and Developmental Immunology)&ltdiv id=&quotmedworm&quot&gt&ltp&gt&ltb&gt&lti&gtMedWorm Sponsor Message:&lt/i&gt&lt/b&gt Find outside how you can &lta href=&quothttp://frankiespeakingfrankly.blogspot.com/2011/04/fresh-medworm-blast-provide.html&quot target=&quot_self&quot&gtget your message posted here and on more than 100,000 other medical web pages&lt/a&gt in just a couple of days, plus support MedWorm at the same age.&lt/p&gt&lt/div&gt Much more info: Informations...