Development of Nephrotic Syndrome after Administration of Sorafenib in a Case of Metastatic Renal Cell Carcinoma

Nephrotic syndrome, after administration of tyrosine kinase inhibitors, is uncommon and not well known. A 62-year-ancient male, who had experienced a left nephrectomy due to a traffic accident 38 years ago, underwent a partial nephrectomy for fair renal cell carcinoma (RCC). Histologically, the tumor was a clear cell RCC. Two years later abdominal CT revealed para-aortic lymph node metastasis. During these two years, serum creatinine had increased from 2.0&#x2009;mg/dL to 2.9&#x2009;mg/dL along with the appearance of proteinuria. After only a week of sorafenib, 400&#x2009;mg/day, fever developed and sorafenib was stopped. Although normotensive, his serum creatinine increased to 3.83&#x2009;mg/dL and serum albumin decreased from 1.8&#x2009;g/L to 1.0&#x2009;g/L. Proteinuria also worsened to 27...<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Please listen to <a href="https://plus.google.com/115738064898291568173/posts/aapMc16itxR" target="_self">this plea of support for the health workers in Bahrain</a>. #FreeDoctors</p></div> More information: Check this...