Natural Killer cells and T cells induce various kinds of skin responses throughout recall reactions to haptens

AbstractThe role of T cells in touch hypersensitivity (CHS) to haptens continues to be well referred to. However, recent reviews shown that CHS‐like responses to experimental haptens might be caused in rodents deficient in T cells and B cells, consequently of adaptive‐like options that come with Natural Killer (NK) cells. Here, we in comparison hapten‐specific inflammatory responses caused by memory T cells or NK cells. Classical CHS methods were put on wild‐type or T‐ and B‐cell deficient rodents. Adoptive transfers of hapten‐specific T cells and NK cells were also carried out. Liver NK cells from hapten‐primed rodents caused specific recall reactions to haptens upon transfer in CD3ε deficient rodents, thus verifying the presence of “reminiscence” NK cells within the liver. We looked into the nat...

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