Recognition of paternal trophoblast HLA-C by maternal uterine NK cell KIR determines the outcome of pregnancy

Introduction: Successful pregnancy requires that trophoblast invasion of the uterus be appropriately calibrated to ensure that neither fetus nor mother is compromised. We have investigated the regulation of placentation by interactions between maternal KIR on uterine Natural Killer cells (uNK) and HLA-C expressed by fetal trophoblast. (Source: Journal of Reproductive Immunology) More information: More info...