BST-2/tetherin is a host antiviral molecule that functions to potently inhibit the release of enveloped viruses from infected cells. In giveback, viruses have evolved antagonists to this activity. BST-2 traps budding virions by using two separate membrane-anchoring regions that simultaneously incorporate into the host and viral membranes. Here, we detailed the structural and biophysical properties of the complete-length BST-2 ectodomain, which spans the two membrane anchors. The 1.6-Å crystal structure of the complete mouse BST-2 ectodomain reveals an ∼145-Å parallel dimer in an extended α-helix conformation that predominantly forms a coiled coil bridged by three intermolecular disulfides that are required …
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Atopic disease linked to increased thrombosis risk
Patients with venous thromboembolism are nearly twice as likely to have atopic diseases, such as allergic rhinitis, as individuals with no history of thrombosis, researchers report. (Source: MedWire News - Thrombosis)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Watch the fresh <a href="http://frankiespeakingfrankly.blogspot.com/2010/10/medworm-googlereader-video-demo.html" target="_self">MedWorm demo</a> and find outside how to get all the very latest, relevant, organized data daily!</p></div> More information: Click here...
Teen With Progressive Depigmented Patches
This 16-year-ancient boy had slowly progressive hypopigmented lesions on
the lower extremities for the past 4 years. He also had atopic dermatitis,
asthma, and allergic rhinitis. (Source: Consultant Live)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Watch the fresh <a href="http://frankiespeakingfrankly.blogspot.com/2010/10/medworm-googlereader-video-demo.html" target="_self">MedWorm demo</a> and find outside how to get all the very latest, relevant, organized data daily!</p></div> More information: More infos...
Tags: Health, div id, lesions, Consultant Live, div, Sponsor…
Clinical analysis of high serum IgE in autoimmune pancreatitis.
CONCLUSION: Although IgE does not necessarily reflect the disease activity, IgE might be useful for the diagnosis of AIP in an inactive stage.
PMID: 21049558 [PubMed - in action] (Source: Earth Journal of Gastroenterology : WJG)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Watch the fresh <a href="http://frankiespeakingfrankly.blogspot.com/2010/10/medworm-googlereader-video-demo.html" target="_self">MedWorm demo</a> and find outside how to get all the very latest, relevant, organized data daily!</p></div> More information: Click here...
Pharmacists state ambition to expand their role in community health
(Source: BMJ Online First)<div id="medworm"><p><b><i>MedWorm Sponsor Message:</i></b> Watch the fresh <a href="http://frankiespeakingfrankly.blogspot.com/2010/10/medworm-googlereader-video-demo.html" target="_self">MedWorm demo</a> and find outside how to get all the very latest, relevant, organized data daily!</p></div> More information: Full article...
Tags: pharmacists, Health, community health, Source, bmj, div…
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