Tag Archives: FEV

Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial

by on 07. Oct, 2011 in Health

Background:
Fluticasone furoate (FF) is a novel extended-acting inhaled corticosteroid (ICS). This double-blind, placebo-controlled randomized study evaluated the efficacy and safety of FF 200 mcg or 400 mcg once daily, either in the morning or in the evening, and FF 200 mcg twice daily (morning and evening), for 8 weeks in patients with persistent asthma.
Methods:
Asthma patients maintained on ICS for [greater than or equal to]3 months with baseline morning forced expiratory volume in one second (FEV1) 50-80% of predicted normal value and FEV1 reversibility of [greater than or equal to]12% and [greater than or equal to]200 ml were …

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-2 Agonists in sport: would be the anti-doping rules meeting the requirements of asthmatic sports athletes?

by on 12. Jul, 2011 in Health

Conclusions

The anti-doping rules regarding &a-2 agonists demand to become examined, and measures ought to be adopted to understand an autumn of 70% in FEV1% being an obstruction qualifying criterion to point a bronchodilation check and also to extend the qualifying criterion for an optimistic methacholine check to some PC20 of 8 mg/ml. (Source: British Journal of Sports Medicine) More details: Read more...

Tags: British, Source, fev1, comprehend, Health…

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Evaluation of impulse oscillometry during bronchial challenge testing in children

by on 03. Jun, 2011 in Health

ConclusionThe accuracy of measurements by IOS during methacholine bronchial challenge in children was not suitable when compared with FEV1. It could be assumed that spirometry and IOS, while both providing indirect indices of airway patency, are exploring different mechanisms, each with its own methodological potentials and limitations. Pediatr Pulmonol. © 2011 Wiley‐Liss, Inc. (Source: Pediatric Pulmonology) More information: Click here...

Tags: accuracy, liss, Source, Inc, FEV, Health…

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Sputum IL-6 concentrations in serious asthma and its relationship with FEV1

by on 25. May, 2011 in Health

As asthma becomes much more severe it adopts extra characteristics including corticosteroid refractoriness and a neutrophil-predominant inflammatory response implicating Th1 or Th17 responses involving cytokines such as tumour necrosis factor &ampalpha, interleukin (IL)-6 and IL-8. We have examined the role of IL-6 and IL-8 in severe asthma. Subjects with severe asthma (GINA stage IV) who were exacerbation-autonomous of charge for &ampge4&ampnbspweeks with a forced expiratory volume in 1&ampnbsps (FEV1) &ampgt30% nevertheless &amplt80% predicted were studied from the baseline parameters of a clinical trial.1 Cell counts and cytokines were measured in induced sputum (see on-line supplement for Methods). Eighteen subjects …

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Airway refractoriness to inhaled mannitol after repeated challenge

by on 27. Apr, 2011 in Health

This study aimed to investigate whether repeated challenge with mannitol induces refractoriness, as with exercise.Forty‐one children with asthma underwent two consecutive dose–response mannitol challenges (Phase 1); the second challenge proceeded after recovery (FEV1: 95% or more of baseline value) from the first. The response to mannitol was expressed as a provocative dose causing a 15% fall in FEV1 (PD15) and the response–dose ratio (RDR) (% fall in FEV1/cumulative dose). In 18 subjects who were deemed to have mannitol refractoriness in Phase 1, a mannitol challenge was performed before and after a methacholine challenge (Phase 2).In Phase 1, the age taken …

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