Authors: Larsson AK, Hagfjärd A, Dahlén SE, Adner M
Abstract
Prostaglandin D(2) (PGD(2)), launched through mast cell activation, can be used like a non-invasive biomarker in patients with bronchial asthma. Since PGD(2) can elicit opposing effects on airway tone via activation from the PGD(2) receptors DP(1) and DP(2) along with the thromboxane receptor TP, the goal of the study ended up being to characterize the receptors which are triggered by PGD(2) within the guinea pig lung parenchyma. PGD(2) and also the thromboxane analog U46619 caused concentration-dependent contractions. U46619 was stronger and triggered more powerful effect than PGD(2). The particular …