Authors: Yao X, Remaley AT, Levine SJ
Abstract
Fresh remedies are essential for patients with severe bronchial asthma. We hypothesized that the scientifically relevant experimental imitation of house dust mite (HDM)-caused murine bronchial asthma could be employed to learn fresh paths that regulate disease severity. In HDM-challenged rodents, genome-wide expression profiling from the asthmatic lung transcriptome recognized apolipoprotein E (apoE) like a steroid-unresponsive gene with regularly upregulated expression despite dexamethasone treatment. ApoE and low-density lipoprotein receptor (LDLR) knockout rodents were utilised to show that apoE, that is created by lung macrophages, functions inside a paracrine fashion by binding …
